PhD position in Chemistry of Biomolecules - IPREM, Université de Pau et des Pays de l’Adour : Novel Chemical Approaches to Ultratrace Selenoproteomics
This project proposes the development of novel chemical approaches for the characterization of selenoproteome. This strategy will be based on the synthesis of new solid supported reagents able to selectively bind Seleno Cysteines (SeCys) of selenoproteins in Cys-containing proteins. Starting from biological matrices, our tools will allow for selective recovery and reconcentration of selenoproteins for proteomic characterization and quantification.
This approach focuses on the understanding of the SeCys chemistry in order to develop new “fishing tools” that would offer an opportunity for the proteomic analysis of selenoproteins (evoked in the context of cardiomyopathy, cancer, fertility, aging…) using cutting-edge proteomics approaches.PhD Lobinski_Ronga.pdf
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