La réunion vise à rassembler les équipes françaises intéressées par les peptides antimicrobiens (PAM), à favoriser les échanges scientifiques et à stimuler les synergies entre les différentes disciplines. La participation des jeunes chercheurs est fortement encouragée. Date limite de soumission des présentations orales ou par affiches : 1 octobre 2023
Pour en savoir plus: MuFoPAMArticles mis à l’honneur par le GFPP!
|The environment shapes immune peptides|
Antimicrobial peptides (AMPs) play a key role in the external immunity of animals, offering an interesting model for studying the influence of the environment on the diversification and evolution of immune effectors. Alvinellacin (ALV), arenicin (ARE) and polaricin (POL, a novel AMP identified here), characterized from three marine worms inhabiting contrasted habitats (‘hot’ vents, temperate and polar respectively), possess a well conserved BRICHOS domain in their precursor molecule despite a profound amino acid and structural diversification of the C-terminal part containing the core active peptide.(suite…)
|Transporting Cu into Cells with a Peptide|
In Alzheimer’s disease (AD) copper ions accumulates in amyloid plaques, a hallmark of this disease. This copper likely originating from intracellular sources. The Cu in amyloid plaques is bound to its main constituent, the peptide amyloid-β (Aβ). Cu-Aβ can catalyze the production of reactive oxygen species (ROS) in vitro and is thought to contribute to the oxidative stress observed in AD. The paper reports on the development of a novel Cu shuttle able to restore the Cu balance between intra- and extracellular Cu. (suite…)
|Short peptides to replace chemicals in agronomy|
The current agriculture main challenge is to maintain food production while facing multiple threats such as increasing world population, temperature increase, lack of agrochemicals due to health issues and uprising of weeds resistant to herbicides. Developing novel, alternative, and safe methods is hence of paramount importance. Here we show that complementary peptides (cPEPs) from any gene can be designed to target specifically plant coding genes. (suite…)
|Gilles Subra (Zervas Award 2020)|
|Moulding proteins with amino acids|
Gilles Subra received the Zervas award from the EPS in 2022 during the 36th EPS meeting in Sitges (Spain). With this recent article, he shares with us some of the innovative work pursued in his team.
MIP (molecular imprinted polymers) are prepared by polymerizing monomers around a template. After the removal of the template, the cavities in the material will be able to recognise and recapture selectively the molecule of interest. (suite…)