|Best oral communication awards|
GFPP23 organized in September 2023 in Fournols (France) gave the opportunity to young talented people to present their latest research. The committee was impressed by the high quality of the oral presentations and has selected two awardees. We warmly thank Genepep for sponsoring the award competition.
GFPP23 awardees are Benjamin Grain (CIIL, Lille, France) and Sonia Khemaissa (LBM, Sorbonne University, France).
Awardee: Benjamin Grain
Title of the oral communication: Fast-SEA: a chemoselective thioester-based ligation reaction for the precise modification of peptides and proteins
Recently, we have developed a chemoselective thioester-based ligation reaction which is highly efficient in highly dilute media (nanomolar concentration range) and which proceeds with rate constants up to 30 M-1 s-1. We now seek to extend this extremely efficient process called Fast-SEA ligation to the selective modification of large polypeptides and proteins. In this regard, we discussed how a latent and highly reactive oxalyl thioester precursor can be efficiently introduced as a pending functionality into a fully synthetic protein domain following a protection/late-stage deprotection strategy. This approach is illustrated with the production of a K48-ubiquitin conjugate.
Title of the article linked to the presentation : Incorporation of a Highly Reactive Oxalyl Thioester-Based Interacting Handle into Proteins
List of authors: Benjamin Grain, Rémi Desmet, Benoît Snella, Oleg Melnyk, and Vangelis Agouridas
Citation: Organic Letters 2023, 25, 5117-5122.
Laboratory: Center for Infection and Immunity of Lille (CIIL)