The three main approaches commonly employed for peptide synthesis are solution synthesis or also called classical solution-phase peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase peptide synthesis (LPPS).
ABSTRACT
Various approaches to make peptides have been adopted globally owing to their high demand. The three main approaches commonly used for this purpose are solution synthesis, also called classical solution-phase peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase peptide synthesis (LPPS). Each method offers unique advantages: CSPS for scalability, SPPS for automation and efficiency, and LPPS for combining solution-phase simplicity with iterative synthesis using soluble tags.
