“Cell-Penetrating Peptides: From molecular mechanisms to therapeutic applications”
My interest centers on transforming peptides into cell-permeable in vivo active therapeutic compounds and the design of molecular tools to validate their activity in vitro and in vivo. I combine multidisciplinary theoretical and experimental methods to understand the mechanisms of uptake of cell-penetrating peptides and tackle this property to design cell-permeable therapeutic peptides. As an undergraduate I studied physics in Argentina (Institute Balseiro), obtained a PhD in physics in US (North Carolina State University), as a postdoc I trained on bioinformatics in US (Rensselaer Polytechnic Institute) and on Biology in Germany (Technische Universität Darmstadt). During this time I focused on arginine-rich cell-penetrating peptides. Currently I am at Harvard Medical School and Dana-Farber Cancer Institute developing therapeutic cell-permeable stapled peptides.