Groupe Français des Peptides et des Protéines
The Compliance Leader will be working as part of the Corden Pharma Brussels Quality Assurance Department and ensure that the products are manufactured, stored and packaged in accordance with cGMP regulation. The Compliance Leader will be working as part of the Quality Unit on site ensuring products are manufactured, stored and packaged in accordance with the cGMP. Under the direction of the Head of Quality, he/she will be in charge to improve continuously the Quality system regarding the cGMP requirements. He/She will be a QA support in case of quality issues and problem solving techniques to assure the successful outcomes of company and external Health Authority. He/She will be in direct contact with our customer in case of qualification audit, QA complaint issues and other quality topics. The Compliance Leader is reporting to the Head of Quality.
November 22, 2019 | Brussels, Belgium
The objective of the event is to discuss the multifaceted therapeutic potential of peptides. Topics such as peptidomimetics and macrocycles, protein-protein interactions, peptide shuttles, chemical ligation and main aspects of peptide synthesis will be tackled.
The confirmed speakers are:
• Linkers for Peptide Conjugation
Prof. Fernando Albericio, University of Kwazulu-Natal, South Africa
• Synthetic Immune System Engagers – a Peptide-based Approach to Immune-oncology
Prof. Christian Becker, University of Vienna, Austria
• From Structure to Function: Peptide Recognition at G Protein-coupled Receptors
Dr Anette Kaiser, University of Leipzig, Germany
• Macrocyclization as an Enabling Tool Toward Novel Peptide Drug Candidates
Prof. Eric Marsault, University of Sherbrooke, Canada
• Targeting Receptor Complexes: A New Dimension in Drug Discovery
Prof. Kristian Strømgaard, University of Copenhagen, Denmark
• Gate2Brain, Opening the Gate to CNS Therapies
Dr Meritxell Teixido, Institute for Research in Biomedicine, Spain
All participants are invited to submit abstracts for scientific communications. Out of the submitted proposals, 3 Oral Communications will be selected. The other accepted abstracts will get the opportunity to be presented as Posters.
Submission deadline: October 10, 2019
More information is available on www.medchem.be
Closing lecture
Orléans is located 110 km north of Paris. There is regular trains from Paris Austerlitz station and from Tours train station (both around 1 h travel), as well as direct shuttles from the two Paris airports (Orly and Roissy-Charles de Gaulles).
The conference venue is unique. Located right next to the Orléans’ cathedral, the episcopal palace of Orléans, built between 1635 and 1641, locally known as the Hôtel Dupanloup, is a classical French building which served until 1905 of residence to the bishops of Orléans. Since 2014, the renewed palace hosts the International University Center for Research and Le Studium Loire Valley Institute for Advanced Studies.
Participants will be welcomed in this exceptional surrounding, blending Middle Age and Renaissance cultures with modern design and will have the opportunity to discover French cuisine and wines.
Venue adress: 1, rue Dupanloup – 45000 ORLEANS – FR
Hôtel Dupanloup is 10 min walk from Orléans train station. Alternatively, you can take tram A to De Gaulle station then tram B to Cathédrale-Hôtel de Ville station.
Organizing committee:
Scientific committee:
CNRS Center for Molecular Biophysics (CBM), Orléans, France
November 18th, 2019 : deadline for oral communication submission
December 2nd, 2019 : deadline for poster submission. January 20th, 2020 : end of registration.
| Registration types | Registration Fees |
| PhD student | 75 € |
| Academic delegate | 180 € |
| Private company delegate | 250 € |
Deadline for submitting an abstract for oral communication ended on November 18th, 2019, and the oral communication selection process is now over (see the selected oral communications at the bottom of the page) .
Deadline for submitting an abstract for poster communication has been postponed to January 17th, 2020
Please upload your abstract during the registration or send it before the deadline to maurine.villiers@lestudium-ias.fr.
Note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.
Please download the template for poster presentation.
List of the oral communications selected from the submitted abstracts:
| Name | Organisation | Country | Abstract title |
| Dr Elisabeth Garanger | University of Bordeaux | France | Expanding the toolbox of chemoselective modifications of protein-like polymers at methionyl residues |
| Dr Gosuke Hayashi | Nagoya University | Japan | Chemical synthesis of histone proteins through novel ligation strategies |
| Dr Samir Messaoudi | Paris-Sud University | France | Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation |
| Dr Pierre Milbeo | Trinity College of Dublin | Ireland | Development of Novel Thiol-ene Mediated Peptide Ligation Strategies |
| Dr Elisabetta Mileo | Aix-marseille University | France | Nitroxide-based spin tags coupled to EPR spectroscopy: investigation of protein structural dynamics in vitro and inside cells |
| Dr Laia Miret Casals | Ghent University | Belgium | Furan crosslink technology: from in vitro analysis of peptide-protein interactions to GPCR-ligand interactions on live cells |
| Dr Somnath Mukherjee | University of Vienna | Austria | Impact of site-specific non-enzymatic posttranslational modification on the structure-activity attributes of human Hsp27 |
| Dr Kevin Neumann | ETH Zurich | Switzerland | Cyanosulfurylide as a protecting group for carboxylic acid during peptide synthesis |
| Dr Marina Rubini | University College Dublin | Ireland | Semisynthetic approaches for studying post-translational modifications |
| Mrs Rebecca Schäfer | ETH Zurich | Switzerland | The Bioorthogonal Isonitrile-Chlorooxime Ligation |
| Mr Ruben Tomás | University of Warwick | UK | Controlling Synthetic Polymer Ligation to Metabolically Labelled Cellular Interfaces to Introduce Non-native Functionality. |
| Prof Ping Wang | Shanghai Jiao Tong University | China | Histidine-Specific Peptide Modification via Visible-Light-Promoted C-H Alkylation |
MONDAY JANUARY 27th 2020
The symposium entitled:
Challenges and prospects in chemoselective ligations: from protein synthesis to site-specific conjugation
have been held in Orléans (France), from Monday 27th to Wednesday 29th January 2020.
This three-day international conference was jointly organized by LE STUDIUM Loire Valley Institute for Advanced Studies and the Centre for Molecular Biophysics – CNRS Orléans. This event was held under the auspices of the French Peptide and Protein Group (GFPP) and followed three previous editions (Paris 2001, Lille 2008 and 2016) of short international meetings dedicated to chemical ligation. The official language of this meeting is English.
Recent years have seen an exponentially growing interest in chemical reactions enabling the selective modification of proteins and peptides. These advances are intimately linked to the development of methodologies for protein engineering with an atomic precision, for the generation of well-defined antibody-drug conjugates or on-demand probes to decipher biological processes. Such chemoselective reactions are also widely utilized for the total synthesis and semi-synthesis of proteins through chemical ligation of unprotected peptide fragments, an approach highly complementary to recombinant production. The chemical reactions implemented for both purposes share the same requirements: compatibility with dilute aqueous solution at physiological pH, and tolerance to the myriad functional groups commonly found in biomolecules. These remarkable features inspired the advent of bioorthogonal reactions, which can be carried out in living systems.
Sixteen invited speakers have accepted our invitation and covered the different aspects of these multidisciplinary fields, from methodology development to biological applications. In addition, contributions selected from submitted abstracts have been presented as oral communication and poster.
Forthcoming thematic days organized under the auspices of GFPP
Invited speakers
Please find below the finalized speaker list, after a couple of last minute changes.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Germany
« C─H Activation as an Transformative Tool for Late-stage Diversification of Biomolecules »
University of Cambridge, UK
Royal Society Newton International Fellow in Prof. Gonçalo BERNARDES group
« Title to be announced »
Department de Chimie Moléculaire, University of Grenoble, France
« Design of peptide vectors through chemoselective ligations »
Laboratoire des Biomolécules, Sorbonne University, Paris, France
« Extending chemical ligation for protein synthesis: Application to NEMO ubiquitylation »
Faculty of Pharmacy, University of Groningen, Netherlands
« Multicomponent reaction chemistry: From novel small molecules to automated nano chemistry to stapled peptides. »
École Polytechnique Fédérale de Lausanne, Switzerland
« Synthetic and single-molecule exploration of the dynamic chromatin landscape »
Department of Chemistry University of California, Berkeley, USA
« Chemoselective Oxidative Coupling Reactions for Protein and Peptide Ligations »
Laboratoire CEISAM University of Nantes, France
« Electrochemically promoted tyrosine-click-chemistry for protein labeling »
Department of Chemistry Texas A&M University, College station, USA
« Phage-Encoded Noncanonical Amino Acids for Drug Discovery »
Institut de Biologie de Lille, Pasteur Institute of Lille, France
« A cysteine selenosulfide redox switch for protein chemical synthesis »
Laboratoire COBRA, Normandy University, Rouen, France
« From organic methodology to the development of chemoselective ligations »
Chemistry and Biology of Metals laboratory, CEA Grenoble, France
« How chemoselective ligations make the design of peptide-based responsive luminescent probes easier »
Laboratoire de toxinologie moléculaire et biotechnologies, CEA Saclay ― France
« Venins, du poison au médicament »
Popularization lecture open to general public (in French)
Molecular labeling and bio-organic chemistry unit, CEA Saclay, France
« Recent advances in fast, bioorthogonal ligation reactions »
Department of Chemistry and Molecular Biology University of Gothenburg, Göteborg, Sweden
« Chemical synthesis of membrane-associated peptides: studies on influenza virus B protein BM2 »
Institut de Science et d’Ingénierie Supramoléculaires, University of Strasbourg, France
« Making order out of protein disorder »
Department of Chemistry Universität Bayreuth, Germany
« Merging Chemistries for the Synthesis and Evaluation of Homogenous Glycoproteins »
Synthetic Biology Group, ACIB – Austrian Centre of Industrial Biotechnology, Graz , Austria
« Engineering of proteins with non-canonical amino acids in industrial biotechnology »
Past thematic days organized under the auspices of GFPP
Tuesday afternoon excursions
The choice between several excursions is proposed for Tuesday afternoon. Either :
Canoe/kayak on the river Loire.
Visit of two wine cellars, including wine tasting sessions: oenotouristic visit of a troglodyte wine cellar, and visit of a family-owned cellar and vineyard.
Visit of the Chenonceau castle.
Visit of the castle of Chaumont-sur-loire and the international garden festival.
Please note that some of the proposed excursions options could finally be unavailable, either in case of weather incompatibilities or a of a too small number of registered participants for a given option. We will keep in touch with registered participants in due course to arrange for an alternative option.
